NEW YORK: Australia's Nick Kyrgios sent defending champion Daniil Medvedev tumbling out of the US Open on Sunday (Monday in Manila) as US teenager Coco Gauff reached the quarterfinals for the first time.

The notoriously temperamental 23rd-seeded Kyrgios produced some scintillating shot-making on his way to a superb 7-6 (13/11), 3-6, 6-3, 6-2 win over the world number one from Russia.

Nick Kyrgios of Australia returns against Daniil Medvedev of Russia during the 2022 US Open at USTA Billie Jean King National Tennis Center on Sunday, Sept. 4, 2022 (September 5 in Manila), in New York. AFP PHOTO
Nick Kyrgios of Australia returns against Daniil Medvedev of Russia during the 2022 US Open at USTA Billie Jean King National Tennis Center on Sunday, Sept. 4, 2022 (September 5 in Manila), in New York. AFP PHOTO

Kyrgios, who was beaten by Novak Djokovic in the Wimbledon final in July, showed grit and composure to save three set points in the opening set before holding his nerve to win an epic tie-break 13/11 before a raucous Arthur Ashe Stadium crowd.

Although he dropped the second set, he roared back to dominate Medvedev in the third and fourth sets to clinch victory in 2hr 53min.

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"It was an amazing match, obviously Daniil as the defending champion had a lot of pressure on his shoulders, but I've been playing amazing the last couple of months," Kyrgios said after the win.

"What a place to do it — packed house in New York. I'm extremely blessed."

Kyrgios will face Karen Khachanov in the quarterfinals on Tuesday. Khachanov equalled his best performance in a Grand Slam event by defeating Spanish 12th seed Pablo Carreno Busta in a 3hr 21min five-set thriller.

The 27th-seeded Khachanov dug deep to down Carreno Busta 4-6, 6-3, 6-1, 4-6, 6-3 on the Louis Armstrong Stadium.

Elsewhere in the fourth round on Sunday, fifth seed Casper Ruud became the first Norwegian man to reach the US Open quarterfinals with a 6-1, 6-2, 6-7 (4/7), 6-2 victory over French lucky loser Corentin Moutet.